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(Abbreviations used in this paper along with their complete names are listed in Glossary.) Figure 1 An important theme in interpreting vitamin B 12 deficiency is the remethylation block hypothesis: Vitamin B 12 deficiency results in hyperhomocysteinemia because Hcy remethylation is blocked (Selhub et al., 2007)

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Redox regulation of HIF-1 Antioxidant/pro-oxidant equilibrium is likely to regulate HIF-1 redox sensitivity [13, 14, 51, 73, 109111]

From a neurobiological perspective, in this stage of the addiction cycle, alcohol consumption is a goal-directed behavior, initiated and executed by brain areas within the executive control network, with its rewarding effects processed by appetitive drive regions (Kyzar and Pandey, 2015)